Assay Detail
Binding
CHEMBL681747
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.11 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77779 | — | — | 1 | 10.00 |
| CHEMBL78704 | — | — | 1 | 10.00 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.62 |
| CHEMBL78646 | — | — | 1 | 6.80 |
| CHEMBL82307 | — | — | 1 | - |
| CHEMBL78807 | — | — | 1 | - |
| CHEMBL310370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77779 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL78704 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL78646 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL82307 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL78807 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL310370 | — | Ki | > | 10000.0 | nM | - |