Assay Detail
Binding
CHEMBL681750
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Displacement of Dexamethasone from human glucocorticoid receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.70 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 7.88 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL114941 | — | — | 1 | 7.29 |
| CHEMBL322108 | — | — | 1 | 6.89 |
| CHEMBL114607 | — | — | 1 | 6.80 |
| CHEMBL116221 | — | — | 1 | 6.58 |
| CHEMBL286446 | — | — | 1 | 6.43 |
| CHEMBL112987 | — | — | 1 | 6.41 |
| CHEMBL326092 | — | — | 1 | 6.27 |
| CHEMBL116007 | — | — | 1 | 6.13 |
| CHEMBL325221 | — | — | 1 | 6.09 |
| CHEMBL8639 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL103 | PROGESTERONE | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL114941 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL322108 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL114607 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL116221 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL286446 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL112987 | — | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL326092 | — | Ki | = | 533.0 | nM | 6.27 |
| CHEMBL116007 | — | Ki | = | 749.0 | nM | 6.13 |
| CHEMBL325221 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL8639 | — | Ki | = | 889.0 | nM | 6.05 |