Assay Detail
Functional
CHEMBL681827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.71 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 5.39 |
| CHEMBL55140 | — | — | 1 | 5.36 |
| CHEMBL294192 | — | — | 1 | 5.31 |
| CHEMBL340034 | — | — | 1 | 5.28 |
| CHEMBL434024 | — | — | 1 | 5.24 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.16 |
| CHEMBL291736 | — | — | 1 | 5.13 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.11 |
| CHEMBL301247 | — | — | 1 | 5.11 |
| CHEMBL56011 | — | — | 1 | 5.05 |
| CHEMBL125887 | — | — | 1 | 5.00 |
| CHEMBL294191 | — | — | 1 | 5.00 |
| CHEMBL55608 | (BUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.99 |
| CHEMBL54472 | N-(HEXAMETHYLENEIMINO)METHYLENEBISPHOSPHONIC ACID | — | 1 | 4.95 |
| CHEMBL53950 | INCADRONIC ACID | 2.0 | 1 | 4.94 |
| CHEMBL55959 | — | — | 1 | 4.92 |
| CHEMBL55557 | — | — | 1 | 4.90 |
| CHEMBL301065 | — | — | 1 | 4.84 |
| CHEMBL299717 | (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.74 |
| CHEMBL301244 | — | — | 1 | 4.71 |
| CHEMBL55886 | — | — | 1 | 4.67 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.60 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 4.50 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.40 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.40 |
| CHEMBL55352 | (DIPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.39 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.36 |
| CHEMBL55812 | OLPADRONIC ACID | 2.0 | 1 | 4.33 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 4.27 |
| CHEMBL54926 | (CYCLOBUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL55140 | — | IC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL294192 | — | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL340034 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL434024 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL291736 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL301247 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL56011 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL125887 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL294191 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL55608 | (BUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL54472 | N-(HEXAMETHYLENEIMINO)METHYLENEBISPHOSPHONIC ACID | IC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL53950 | INCADRONIC ACID | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL55959 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL55557 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL301065 | — | IC50 | = | 14454.4 | nM | 4.84 |
| CHEMBL299717 | (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL301244 | — | IC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL55886 | — | IC50 | = | 21379.62 | nM | 4.67 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL55352 | (DIPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 40738.03 | nM | 4.39 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 43651.58 | nM | 4.36 |
| CHEMBL55812 | OLPADRONIC ACID | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 53703.18 | nM | 4.27 |
| CHEMBL54926 | (CYCLOBUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 56234.13 | nM | 4.25 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL55358 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL54537 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL52137 | — | IC50 | = | 66069.34 | nM | 4.18 |
| CHEMBL417549 | (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 66069.34 | nM | 4.18 |
| CHEMBL299988 | — | IC50 | = | 91201.08 | nM | 4.04 |
| CHEMBL316844 | — | IC50 | = | 97723.72 | nM | 4.01 |
| CHEMBL417932 | — | IC50 | = | 251188.64 | nM | - |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 131825.67 | nM | - |
| CHEMBL299563 | THIOMORPHOLINOMETHYLENEDIPHOSPHONIC ACID | IC50 | = | 190546.07 | nM | - |
| CHEMBL298771 | — | IC50 | = | 102329.3 | nM | - |
| CHEMBL55264 | — | IC50 | = | 213796.21 | nM | - |
| CHEMBL55214 | NERIDRONIC ACID | IC50 | = | 194984.46 | nM | - |
| CHEMBL293522 | — | IC50 | = | 229086.77 | nM | - |
| CHEMBL56556 | — | IC50 | = | 398107.17 | nM | - |