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Assay Detail

CHEMBL682006

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human purified factor Xa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR.
Bioorg Med Chem Lett (2003) 13 : 369 -373
PubMed 12565931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.68 10.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332157 1 10.43
CHEMBL333270 1 9.46
CHEMBL441283 1 9.41
CHEMBL442766 1 9.01
CHEMBL331951 1 8.92
CHEMBL123033 1 8.54
CHEMBL122902 1 8.52
CHEMBL333806 1 8.48
CHEMBL123272 1 8.27
CHEMBL340577 1 8.10
CHEMBL124834 1 8.10
CHEMBL122796 1 7.89
CHEMBL122456 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332157 Ki = 0.037 nM 10.43
CHEMBL333270 Ki = 0.35 nM 9.46
CHEMBL441283 Ki = 0.39 nM 9.41
CHEMBL442766 Ki = 0.98 nM 9.01
CHEMBL331951 Ki = 1.2 nM 8.92
CHEMBL123033 Ki = 2.9 nM 8.54
CHEMBL122902 Ki = 3.0 nM 8.52
CHEMBL333806 Ki = 3.3 nM 8.48
CHEMBL123272 Ki = 5.4 nM 8.27
CHEMBL340577 Ki = 8.0 nM 8.10
CHEMBL124834 Ki = 8.0 nM 8.10
CHEMBL122796 Ki = 13.0 nM 7.89
CHEMBL122456 Ki = 19.0 nM 7.72