Assay Detail
Binding
CHEMBL682015
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In vitro inhibitory activity against factor Xa
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.81 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349290 | — | — | 1 | 9.21 |
| CHEMBL164426 | — | — | 1 | 9.15 |
| CHEMBL406940 | — | — | 1 | 9.05 |
| CHEMBL162457 | — | — | 1 | 9.00 |
| CHEMBL163213 | — | — | 1 | 9.00 |
| CHEMBL163401 | — | — | 1 | 9.00 |
| CHEMBL159734 | — | — | 1 | 8.70 |
| CHEMBL163799 | — | — | 1 | 8.70 |
| CHEMBL423284 | — | — | 1 | 8.70 |
| CHEMBL166258 | — | — | 1 | 8.70 |
| CHEMBL445385 | — | — | 1 | 8.52 |
| CHEMBL350629 | — | — | 1 | 8.52 |
| CHEMBL351735 | — | — | 1 | 8.52 |
| CHEMBL163121 | — | — | 1 | 8.40 |
| CHEMBL161881 | — | — | 1 | 8.30 |
| CHEMBL162669 | — | — | 1 | 8.30 |
| CHEMBL349745 | — | — | 1 | 8.22 |
| CHEMBL163809 | — | — | 1 | 8.22 |
| CHEMBL262186 | — | — | 1 | 8.10 |
| CHEMBL349629 | — | — | 1 | 8.00 |
| CHEMBL163437 | — | — | 1 | 8.00 |
| CHEMBL265997 | — | — | 1 | 7.89 |
| CHEMBL162909 | — | — | 1 | 7.77 |
| CHEMBL423281 | — | — | 1 | 7.68 |
| CHEMBL350650 | — | — | 1 | 7.54 |
| CHEMBL164481 | — | — | 1 | 7.50 |
| CHEMBL351180 | — | — | 1 | 7.42 |
| CHEMBL162237 | — | — | 1 | 7.24 |
| CHEMBL166317 | — | — | 1 | 7.19 |
| CHEMBL423421 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349290 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL164426 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL406940 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL162457 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL163213 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL163401 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL159734 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL163799 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL423284 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL166258 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL350629 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL351735 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL445385 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL163121 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL162669 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL161881 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL349745 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL163809 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL262186 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL349629 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL163437 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL265997 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL162909 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL423281 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL350650 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL164481 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL351180 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL162237 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL166317 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL423421 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL159716 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL163062 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL163588 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL162726 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL162839 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL162160 | — | IC50 | = | 771.0 | nM | 6.11 |
| CHEMBL351052 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL351982 | — | IC50 | = | 24000.0 | nM | 4.62 |