Assay Detail
Binding
CHEMBL682020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against serine protease factor Xa (fXa)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.82 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431461 | — | — | 1 | 6.96 |
| CHEMBL92614 | — | — | 1 | 6.80 |
| CHEMBL92406 | — | — | 1 | 6.70 |
| CHEMBL327560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431461 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL92614 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL92406 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL327560 | — | Ki | > | 1200.0 | nM | - |