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Assay Detail

CHEMBL682033

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Effective concentration against Farnesoid X receptor (FXR)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Bile acid receptor (CHEMBL2047)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM.
J Med Chem (2002) 45 : 3569 -3572
PubMed 12166927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 6 6.31 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL318457 1 7.43
CHEMBL566315 OBETICHOLIC ACID 4.0 1 7.00
CHEMBL3137829 1 6.12
CHEMBL3138184 1 5.96
CHEMBL240597 CHENODIOL 4.0 1 5.06
CHEMBL3137828 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL318457 EC50 = 37.0 nM 7.43
CHEMBL566315 OBETICHOLIC ACID EC50 = 99.0 nM 7.00
CHEMBL3137829 EC50 = 750.0 nM 6.12
CHEMBL3138184 EC50 = 1110.0 nM 5.96
CHEMBL240597 CHENODIOL EC50 = 8660.0 nM 5.06
CHEMBL3137828 EC50 > 30000.0 nM -