Assay Detail
Binding
CHEMBL682134
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Inhibition of [3H]muscimol binding to GABA-A receptor of rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.77 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112203 | — | — | 1 | 5.77 |
| CHEMBL325921 | — | — | 1 | - |
| CHEMBL301742 | ARBACLOFEN | 3.0 | 1 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 1 | - |
| CHEMBL302213 | — | — | 1 | - |
| CHEMBL112710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112203 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL325921 | — | IC50 | - | nM | - | |
| CHEMBL301742 | ARBACLOFEN | IC50 | = | 964000.0 | nM | - |
| CHEMBL701 | BACLOFEN | IC50 | = | 1047000.0 | nM | - |
| CHEMBL302213 | — | IC50 | = | 1564000.0 | nM | - |
| CHEMBL112710 | — | IC50 | - | nM | - |