Assay Detail
Binding
CHEMBL682160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.71 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 10.70 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.15 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 8.68 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 8.39 |
| CHEMBL286452 | ALFATRADIOL | 2.0 | 1 | 8.35 |
| CHEMBL31721 | — | — | 1 | 7.82 |
| CHEMBL431698 | RALOXIFENE CORE | — | 1 | 7.77 |
| CHEMBL31684 | — | — | 1 | 7.50 |
| CHEMBL32511 | — | — | 1 | 6.78 |
| CHEMBL31685 | — | — | 1 | 6.76 |
| CHEMBL32072 | — | — | 1 | 6.73 |
| CHEMBL284054 | — | — | 1 | 6.61 |
| CHEMBL31236 | — | — | 1 | 6.59 |
| CHEMBL31333 | — | — | 1 | 6.52 |
| CHEMBL32459 | — | — | 1 | 6.28 |
| CHEMBL418212 | — | — | 1 | - |
| CHEMBL284949 | — | — | 1 | - |
| CHEMBL280645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411 | DIETHYLSTILBESTROL | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1405 | ESTRONE | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL44 | GENISTEIN | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL286452 | ALFATRADIOL | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL31721 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL431698 | RALOXIFENE CORE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL31684 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL32511 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL31685 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL32072 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL284054 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL31236 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL31333 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL32459 | — | EC50 | = | 525.0 | nM | 6.28 |
| CHEMBL418212 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL284949 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL280645 | — | EC50 | > | 1000.0 | nM | - |