Assay Detail
Functional
CHEMBL682161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity in transcriptional activation assay in SH-SY5Y neuroblastoma cells expressing Estrogen receptor beta
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.89 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.00 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 8.77 |
| CHEMBL431698 | RALOXIFENE CORE | — | 1 | 8.00 |
| CHEMBL31684 | — | — | 1 | 7.89 |
| CHEMBL31721 | — | — | 1 | 7.80 |
| CHEMBL32511 | — | — | 1 | 7.16 |
| CHEMBL31685 | — | — | 1 | 6.92 |
| CHEMBL32072 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL44 | GENISTEIN | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL431698 | RALOXIFENE CORE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL31684 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL31721 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL32511 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL31685 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL32072 | — | EC50 | = | 257.0 | nM | 6.59 |