Assay Detail
Binding
CHEMBL682162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.33 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 8.05 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.62 |
| CHEMBL31684 | — | — | 1 | 6.94 |
| CHEMBL431698 | RALOXIFENE CORE | — | 1 | 6.94 |
| CHEMBL31721 | — | — | 1 | 6.89 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.70 |
| CHEMBL32459 | — | — | 1 | 6.60 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 6.58 |
| CHEMBL284054 | — | — | 1 | 6.13 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 5.95 |
| CHEMBL286452 | ALFATRADIOL | 2.0 | 1 | 5.91 |
| CHEMBL31333 | — | — | 1 | 5.74 |
| CHEMBL32072 | — | — | 1 | 5.41 |
| CHEMBL32511 | — | — | 1 | 5.37 |
| CHEMBL31236 | — | — | 1 | 5.33 |
| CHEMBL280645 | — | — | 1 | 5.13 |
| CHEMBL418212 | — | — | 1 | - |
| CHEMBL284949 | — | — | 1 | - |
| CHEMBL31685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411 | DIETHYLSTILBESTROL | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL135 | ESTRADIOL | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL31684 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL431698 | RALOXIFENE CORE | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL31721 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL44 | GENISTEIN | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL32459 | — | EC50 | = | 249.0 | nM | 6.60 |
| CHEMBL81 | RALOXIFENE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL284054 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1405 | ESTRONE | EC50 | = | 1135.0 | nM | 5.95 |
| CHEMBL286452 | ALFATRADIOL | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL31333 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL32072 | — | EC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL32511 | — | EC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL31236 | — | EC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL280645 | — | EC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL418212 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL284949 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL31685 | — | EC50 | > | 10000.0 | nM | - |