Assay Detail
Binding
CHEMBL682169
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Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement.
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.30 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.72 |
| CHEMBL77620 | — | — | 1 | 7.05 |
| CHEMBL77609 | — | — | 1 | 7.05 |
| CHEMBL77930 | — | — | 1 | 6.92 |
| CHEMBL74758 | — | — | 1 | 6.70 |
| CHEMBL264862 | — | — | 3 | 6.62 |
| CHEMBL306636 | — | — | 1 | 6.50 |
| CHEMBL74757 | — | — | 1 | 6.48 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.41 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 6.27 |
| CHEMBL77466 | — | — | 1 | 5.96 |
| CHEMBL73989 | — | — | 1 | 5.85 |
| CHEMBL74027 | — | — | 1 | 5.77 |
| CHEMBL77851 | — | — | 1 | 5.58 |
| CHEMBL74022 | — | — | 1 | 5.55 |
| CHEMBL77794 | — | — | 1 | 5.54 |
| CHEMBL307205 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL77609 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL77620 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL77930 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL74758 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL264862 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL264862 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL306636 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL74757 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL44 | GENISTEIN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1405 | ESTRONE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL264862 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL77466 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL73989 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL74027 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL77851 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL74022 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL77794 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL307205 | — | IC50 | = | 5600.0 | nM | 5.25 |