Assay Detail
Binding
CHEMBL682290
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Inhibitory concentration against estrogen receptor alpha using radioligand binding assay.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.44 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113354 | — | — | 1 | 8.40 |
| CHEMBL2137046 | — | — | 1 | 7.77 |
| CHEMBL101382 | — | — | 1 | 7.72 |
| CHEMBL316080 | — | — | 1 | 7.68 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 7.66 |
| CHEMBL100763 | — | — | 1 | 7.57 |
| CHEMBL174502 | — | — | 1 | 7.55 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.55 |
| CHEMBL101807 | — | — | 1 | 7.54 |
| CHEMBL327515 | — | — | 1 | 7.51 |
| CHEMBL328388 | — | — | 1 | 7.51 |
| CHEMBL101997 | — | — | 1 | 7.51 |
| CHEMBL100617 | — | — | 1 | 7.47 |
| CHEMBL103294 | — | — | 1 | 7.46 |
| CHEMBL98558 | — | — | 1 | 7.42 |
| CHEMBL101083 | — | — | 1 | 7.42 |
| CHEMBL319211 | — | — | 1 | 7.41 |
| CHEMBL98470 | — | — | 1 | 7.36 |
| CHEMBL100595 | — | — | 1 | 7.34 |
| CHEMBL103305 | — | — | 1 | 7.31 |
| CHEMBL328810 | — | — | 1 | 7.25 |
| CHEMBL319678 | — | — | 1 | 7.18 |
| CHEMBL100231 | — | — | 1 | 7.15 |
| CHEMBL101719 | — | — | 1 | 7.15 |
| CHEMBL323119 | — | — | 1 | 7.03 |
| CHEMBL103650 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113354 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2137046 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL101382 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL316080 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL100763 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL174502 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL101807 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL327515 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL328388 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL101997 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL100617 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL103294 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL98558 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL101083 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL319211 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL98470 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL100595 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL103305 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL328810 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL319678 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL100231 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL101719 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL323119 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL103650 | — | IC50 | = | 285.0 | nM | 6.54 |