Assay Detail
Binding
CHEMBL682298
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Binding affinity for estrogen receptor alpha
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.29 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.40 |
| CHEMBL2137046 | — | — | 1 | 9.30 |
| CHEMBL58688 | — | — | 1 | 9.22 |
| CHEMBL56198 | — | — | 1 | 9.22 |
| CHEMBL56390 | — | — | 1 | 9.05 |
| CHEMBL56306 | — | — | 1 | 8.96 |
| CHEMBL60538 | — | — | 1 | 8.77 |
| CHEMBL293297 | — | — | 1 | 8.60 |
| CHEMBL59146 | — | — | 1 | 7.54 |
| CHEMBL59311 | — | — | 1 | 7.43 |
| CHEMBL56166 | — | — | 1 | 7.06 |
| CHEMBL293599 | — | — | 1 | 6.77 |
| CHEMBL59438 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL2137046 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL58688 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL56198 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL56390 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL56306 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL60538 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL293297 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL59146 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL59311 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL56166 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL293599 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL59438 | — | Ki | = | 310.0 | nM | 6.51 |