Assay Detail
Binding
CHEMBL682303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.01 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298398 | ANTHRAFLAVICACID | — | 1 | 6.51 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.43 |
| CHEMBL289277 | EMODIN | — | 1 | 6.11 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 5.75 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298398 | ANTHRAFLAVICACID | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL44 | GENISTEIN | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL289277 | EMODIN | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL8145 | DAIDZEIN | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | Ki | = | 5700.0 | nM | 5.24 |