Assay Detail
Functional
CHEMBL682443
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Inhibitory constant against purified Folyl-polyglutamate synthase from mouse liver
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Liver |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.42 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26148 | — | — | 1 | 4.62 |
| CHEMBL275229 | — | — | 1 | 4.21 |
| CHEMBL434004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26148 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL275229 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL434004 | — | Ki | = | 170000.0 | nM | - |