Assay Detail
Binding
CHEMBL682705
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Inhibitory concentration against farnesyltransferase was determined
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.34 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294888 | — | — | 1 | 10.22 |
| CHEMBL252953 | — | — | 1 | 9.82 |
| CHEMBL52073 | — | — | 1 | 9.70 |
| CHEMBL54044 | — | — | 1 | 9.22 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.07 |
| CHEMBL27486 | — | — | 1 | 9.00 |
| CHEMBL55826 | — | — | 1 | 8.96 |
| CHEMBL351706 | BMS-214662 | 1.0 | 1 | 8.85 |
| CHEMBL1790332 | — | — | 1 | 8.74 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.72 |
| CHEMBL430778 | — | — | 1 | 7.62 |
| CHEMBL27449 | — | — | 1 | 7.27 |
| CHEMBL55431 | — | — | 1 | 6.75 |
| CHEMBL289404 | — | — | 1 | 6.60 |
| CHEMBL10971 | SCH-37370 | — | 1 | 4.57 |
| CHEMBL279433 | L-778123 FREE BASE | 1.0 | 1 | - |
| CHEMBL442552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294888 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL252953 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL52073 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL54044 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL27486 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL55826 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL351706 | BMS-214662 | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1790332 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL430778 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL27449 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL55431 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL289404 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL279433 | L-778123 FREE BASE | IC50 | = | 2.0 | nM | - |
| CHEMBL442552 | — | IC50 | < | 1.0 | nM | - |