Compound Detail
CHEMBL442552
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Basic Information
| ChEMBL ID | CHEMBL442552 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VWNBOOIWICWEPL-XMMISQBUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
439.5
MW (Da)
3.68
ALogP
6
HBA
1
HBD
83.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | EC50 | 9.74 | 9.74 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | EC50 | = | 0.18 | nM | 9.74 | Effective concentration required to inhibit HDJ2 farnesylation in PSN-1 cells | 15055985 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15055985 | 10.1021/jm0305467 | Protein farnesyltransferase | 2 |
Data from ChEMBL 36 via Core Engine