Assay Detail
Functional
CHEMBL682960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | A10 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.24 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267458 | BMS-182874 | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267458 | BMS-182874 | IC50 | = | 570.0 | nM | 6.24 |