Assay Detail
Binding
CHEMBL682971
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Inhibitory effect against Human Endothelin A receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.28 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336033 | — | — | 1 | 8.08 |
| CHEMBL342615 | — | — | 1 | 7.52 |
| CHEMBL343379 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336033 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL342615 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL343379 | — | IC50 | = | 590.0 | nM | 6.23 |