Assay Detail
Binding
CHEMBL683004
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Inhibition of glycogen synthase kinase-3-alpha/beta (GSK-3-alpha/beta) in porcine brain relative to indirubin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.17 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337300 | — | — | 1 | 8.05 |
| CHEMBL174025 | — | — | 1 | 7.38 |
| CHEMBL367113 | — | — | 1 | 7.30 |
| CHEMBL173682 | — | — | 1 | 7.26 |
| CHEMBL111433 | — | — | 1 | 7.21 |
| CHEMBL173445 | — | — | 1 | 7.17 |
| CHEMBL367345 | — | — | 1 | 7.11 |
| CHEMBL176676 | — | — | 1 | 6.60 |
| CHEMBL173690 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337300 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL174025 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL367113 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL173682 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL111433 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL173445 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL367345 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL176676 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL173690 | — | IC50 | = | 350.0 | nM | 6.46 |