Compound Detail
CHEMBL176676
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL176676 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NRFIAFHOBIQDRE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
420.1
MW (Da)
4.72
ALogP
3
HBA
2
HBD
65.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 | IC50 | = | 250.0 | nM | 6.6 | Inhibition of glycogen synthase kinase-3-alpha/beta (GSK-3-alpha/beta) in porcin... | 14761195 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14761195 | 10.1021/jm031016d | Glycogen synthase kinase-3 | 1 |
Data from ChEMBL 36 via Core Engine