Assay Detail
Binding
CHEMBL683042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human epidermal growth factor receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.87 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301612 | — | — | 1 | 7.11 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 6.46 |
| CHEMBL45827 | — | — | 1 | 6.41 |
| CHEMBL298679 | — | — | 1 | 6.14 |
| CHEMBL51028 | — | — | 1 | 6.06 |
| CHEMBL51485 | — | — | 1 | 6.01 |
| CHEMBL50470 | — | — | 1 | 5.87 |
| CHEMBL49596 | — | — | 1 | 5.25 |
| CHEMBL299194 | — | — | 1 | 5.06 |
| CHEMBL299763 | — | — | 1 | 4.30 |
| CHEMBL50977 | — | — | 1 | - |
| CHEMBL51573 | — | — | 1 | - |
| CHEMBL299347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301612 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL45827 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL298679 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL51028 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL51485 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL50470 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL49596 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL299194 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL299763 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL50977 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL51573 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL299347 | — | IC50 | > | 50000.0 | nM | - |