Assay Detail
Functional
CHEMBL683163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against human small cell lung cancer H69 cell lines
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.79 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133987 | TRIMELAMOL | — | 1 | 5.07 |
| CHEMBL339374 | — | — | 1 | 4.93 |
| CHEMBL334725 | — | — | 1 | 4.89 |
| CHEMBL135064 | — | — | 1 | 4.88 |
| CHEMBL422976 | — | — | 1 | 4.87 |
| CHEMBL134815 | — | — | 1 | 4.49 |
| CHEMBL336275 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133987 | TRIMELAMOL | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL339374 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL334725 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL135064 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL422976 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL134815 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL336275 | — | IC50 | = | 42300.0 | nM | 4.37 |