Assay Detail
Functional
CHEMBL683165
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Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 81 | 6.81 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165023 | — | — | 1 | 7.72 |
| CHEMBL166132 | — | — | 1 | 7.70 |
| CHEMBL163681 | — | — | 1 | 7.68 |
| CHEMBL350316 | — | — | 1 | 7.65 |
| CHEMBL162169 | — | — | 1 | 7.62 |
| CHEMBL350655 | — | — | 1 | 7.60 |
| CHEMBL164477 | — | — | 1 | 7.60 |
| CHEMBL162320 | — | — | 1 | 7.60 |
| CHEMBL163528 | — | — | 1 | 7.60 |
| CHEMBL162231 | — | — | 1 | 7.55 |
| CHEMBL165983 | — | — | 1 | 7.55 |
| CHEMBL162781 | — | — | 1 | 7.54 |
| CHEMBL162318 | — | — | 1 | 7.54 |
| CHEMBL162310 | — | — | 1 | 7.36 |
| CHEMBL165982 | — | — | 1 | 7.32 |
| CHEMBL162451 | — | — | 1 | 7.31 |
| CHEMBL350709 | — | — | 1 | 7.24 |
| CHEMBL165615 | — | — | 1 | 7.21 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.20 |
| CHEMBL163923 | — | — | 1 | 7.17 |
| CHEMBL159861 | — | — | 1 | 7.16 |
| CHEMBL413524 | — | — | 1 | 7.11 |
| CHEMBL349655 | — | — | 1 | 7.11 |
| CHEMBL159920 | — | — | 1 | 7.04 |
| CHEMBL351632 | — | — | 1 | 7.04 |
| CHEMBL349901 | — | — | 1 | 7.03 |
| CHEMBL424182 | — | — | 1 | 7.01 |
| CHEMBL350542 | — | — | 1 | 7.00 |
| CHEMBL163867 | — | — | 1 | 6.99 |
| CHEMBL350797 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165023 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL166132 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL163681 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL350316 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL162169 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL350655 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL164477 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL162320 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL163528 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL162231 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL165983 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL162781 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL162318 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL162310 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL165982 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL162451 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL350709 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL165615 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL163923 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL159861 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL413524 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL349655 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL159920 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL351632 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL349901 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL424182 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL350542 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL163867 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL350797 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL162517 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL349741 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL350794 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL422019 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL424080 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL162601 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL162448 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL348932 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL162112 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL353784 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL351646 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL164742 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL163031 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL163025 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL163393 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL422372 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL163594 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL163399 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL350096 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL162830 | — | IC50 | = | 193.0 | nM | 6.71 |