Assay Detail
Functional
CHEMBL683167
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Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.72 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162885 | — | — | 1 | 9.19 |
| CHEMBL162739 | — | — | 1 | 9.04 |
| CHEMBL353127 | — | — | 1 | 9.02 |
| CHEMBL350147 | — | — | 1 | 8.98 |
| CHEMBL355827 | — | — | 1 | 8.92 |
| CHEMBL162781 | — | — | 1 | 8.92 |
| CHEMBL349474 | — | — | 1 | 8.92 |
| CHEMBL351740 | — | — | 1 | 8.92 |
| CHEMBL162987 | — | — | 1 | 8.92 |
| CHEMBL165348 | — | — | 1 | 8.92 |
| CHEMBL163525 | — | — | 1 | 8.89 |
| CHEMBL162451 | — | — | 1 | 8.85 |
| CHEMBL163577 | — | — | 1 | 8.82 |
| CHEMBL351239 | — | — | 1 | 8.77 |
| CHEMBL162112 | — | — | 1 | 8.72 |
| CHEMBL163072 | — | — | 1 | 8.68 |
| CHEMBL163609 | — | — | 1 | 8.49 |
| CHEMBL433703 | — | — | 1 | 8.35 |
| CHEMBL351244 | — | — | 1 | 8.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.86 |
| CHEMBL163314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162885 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL162739 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL353127 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL350147 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL355827 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL162781 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL349474 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL351740 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL162987 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL165348 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL163525 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL162451 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL163577 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL351239 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL162112 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL163072 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL163609 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL433703 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL351244 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL163314 | — | IC50 | > | 4.0 | nM | - |