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Assay Detail

CHEMBL683176

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Functional
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
ChEMBL ↗
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H69
Confidence 1 — Organism
Curated By Expert

Target

NCI-H69 (CHEMBL614805) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Vicker N, Burgess L, Chuckowree IS, Dodd R, Folkes AJ, Hardick DJ, Hancox TC, Miller W, Milton J, Sohal S, Wang S, Wren SP, Charlton PA, Dangerfield W, Liddle C, Mistry P, Stewart AJ, Denny WA.
J Med Chem (2002) 45 : 721 -739
PubMed 11806724 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 81 6.94 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL84 TOPOTECAN 4.0 1 7.80
CHEMBL162320 — — 1 7.72
CHEMBL165023 — — 1 7.72
CHEMBL350655 — — 1 7.72
CHEMBL163528 — — 1 7.70
CHEMBL163681 — — 1 7.70
CHEMBL350316 — — 1 7.68
CHEMBL166132 — — 1 7.68
CHEMBL165983 — — 1 7.64
CHEMBL162781 — — 1 7.64
CHEMBL163923 — — 1 7.62
CHEMBL162231 — — 1 7.58
CHEMBL53463 DOXORUBICIN 4.0 1 7.56
CHEMBL162169 — — 1 7.55
CHEMBL162310 — — 1 7.52
CHEMBL162318 — — 1 7.47
CHEMBL162451 — — 1 7.46
CHEMBL164477 — — 1 7.46
CHEMBL165982 — — 1 7.46
CHEMBL350709 — — 1 7.41
CHEMBL349655 — — 1 7.40
CHEMBL165615 — — 1 7.40
CHEMBL353784 — — 1 7.35
CHEMBL159861 — — 1 7.31
CHEMBL163594 — — 1 7.31
CHEMBL163867 — — 1 7.19
CHEMBL162112 — — 1 7.17
CHEMBL422372 — — 1 7.11
CHEMBL348932 — — 1 7.10
CHEMBL164613 — — 1 7.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL84 TOPOTECAN IC50 = 15.9 nM 7.80
CHEMBL162320 — IC50 = 19.0 nM 7.72
CHEMBL350655 — IC50 = 19.0 nM 7.72
CHEMBL165023 — IC50 = 19.0 nM 7.72
CHEMBL163528 — IC50 = 20.0 nM 7.70
CHEMBL163681 — IC50 = 20.0 nM 7.70
CHEMBL350316 — IC50 = 21.0 nM 7.68
CHEMBL166132 — IC50 = 21.0 nM 7.68
CHEMBL165983 — IC50 = 23.0 nM 7.64
CHEMBL162781 — IC50 = 23.0 nM 7.64
CHEMBL163923 — IC50 = 24.0 nM 7.62
CHEMBL162231 — IC50 = 26.0 nM 7.58
CHEMBL53463 DOXORUBICIN IC50 = 27.3 nM 7.56
CHEMBL162169 — IC50 = 28.0 nM 7.55
CHEMBL162310 — IC50 = 30.0 nM 7.52
CHEMBL162318 — IC50 = 34.0 nM 7.47
CHEMBL162451 — IC50 = 35.0 nM 7.46
CHEMBL164477 — IC50 = 35.0 nM 7.46
CHEMBL165982 — IC50 = 35.0 nM 7.46
CHEMBL350709 — IC50 = 39.0 nM 7.41
CHEMBL349655 — IC50 = 40.0 nM 7.40
CHEMBL165615 — IC50 = 40.0 nM 7.40
CHEMBL353784 — IC50 = 45.0 nM 7.35
CHEMBL159861 — IC50 = 49.0 nM 7.31
CHEMBL163594 — IC50 = 49.0 nM 7.31
CHEMBL163867 — IC50 = 64.0 nM 7.19
CHEMBL162112 — IC50 = 67.0 nM 7.17
CHEMBL422372 — IC50 = 77.0 nM 7.11
CHEMBL348932 — IC50 = 79.0 nM 7.10
CHEMBL164613 — IC50 = 86.0 nM 7.07
CHEMBL163393 — IC50 = 87.0 nM 7.06
CHEMBL163345 — IC50 = 89.0 nM 7.05
CHEMBL162601 — IC50 = 90.0 nM 7.05
CHEMBL350797 — IC50 = 94.0 nM 7.03
CHEMBL424080 — IC50 = 96.0 nM 7.02
CHEMBL422019 — IC50 = 96.0 nM 7.02
CHEMBL349468 — IC50 = 99.0 nM 7.00
CHEMBL162448 — IC50 = 101.0 nM 7.00
CHEMBL163617 — IC50 = 99.0 nM 7.00
CHEMBL351632 — IC50 = 103.0 nM 6.99
CHEMBL163031 — IC50 = 103.0 nM 6.99
CHEMBL162517 — IC50 = 103.0 nM 6.99
CHEMBL164742 — IC50 = 104.0 nM 6.98
CHEMBL350794 — IC50 = 107.0 nM 6.97
CHEMBL349741 — IC50 = 110.0 nM 6.96
CHEMBL162830 — IC50 = 111.0 nM 6.96
CHEMBL350096 — IC50 = 109.0 nM 6.96
CHEMBL413524 — IC50 = 111.0 nM 6.96
CHEMBL159920 — IC50 = 116.0 nM 6.94
CHEMBL163025 — IC50 = 117.0 nM 6.93