Assay Detail
Functional
CHEMBL683177
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In vitro cytotoxicity against human small cell lung carcinoma H69/P.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.20 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339173 | — | — | 1 | 7.03 |
| CHEMBL134477 | — | — | 1 | 6.98 |
| CHEMBL337416 | — | — | 1 | 6.59 |
| CHEMBL134775 | — | — | 1 | 6.55 |
| CHEMBL134166 | — | — | 1 | 6.46 |
| CHEMBL132791 | — | — | 1 | 6.39 |
| CHEMBL133871 | — | — | 1 | 6.38 |
| CHEMBL132483 | — | — | 1 | 6.36 |
| CHEMBL135956 | — | — | 1 | 6.35 |
| CHEMBL335314 | — | — | 1 | 6.34 |
| CHEMBL337866 | — | — | 1 | 6.30 |
| CHEMBL131786 | — | — | 1 | 6.29 |
| CHEMBL134662 | — | — | 1 | 6.28 |
| CHEMBL134862 | — | — | 1 | 5.91 |
| CHEMBL434034 | — | — | 1 | 5.74 |
| CHEMBL132185 | — | — | 1 | 5.62 |
| CHEMBL133530 | — | — | 1 | 5.41 |
| CHEMBL424080 | — | — | 1 | 4.70 |
| CHEMBL132838 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339173 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL134477 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL337416 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL134775 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL134166 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL132791 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL133871 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL132483 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL135956 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL335314 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL337866 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL131786 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL134662 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL134862 | — | IC50 | = | 1223.0 | nM | 5.91 |
| CHEMBL434034 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL132185 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL133530 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL424080 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL132838 | — | IC50 | > | 100000.0 | nM | - |