Assay Detail
Binding
CHEMBL683310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine receptors: targets for future drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45891 | — | — | 1 | 8.30 |
| CHEMBL285819 | — | — | 1 | 8.10 |
| CHEMBL261482 | — | — | 1 | 8.10 |
| CHEMBL420705 | (S)-PIA | — | 1 | 6.89 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.40 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.10 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.89 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45891 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL285819 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL261482 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL420705 | (S)-PIA | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL113 | CAFFEINE | Ki | = | 80000.0 | nM | 4.10 |