Assay Detail
Binding
CHEMBL683495
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Binding affinity for human glucocorticoid receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.13 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313062 | — | — | 1 | 8.72 |
| CHEMBL79335 | — | — | 1 | 8.38 |
| CHEMBL79807 | — | — | 1 | 8.21 |
| CHEMBL81591 | — | — | 1 | 8.08 |
| CHEMBL311662 | — | — | 1 | 7.70 |
| CHEMBL311034 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313062 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL79335 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL79807 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL81591 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL311662 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL311034 | — | IC50 | = | 20.0 | nM | 7.70 |