Assay Detail
Functional
CHEMBL683542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL1918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.91 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301536 | — | — | 1 | 5.60 |
| CHEMBL51660 | — | — | 1 | 5.21 |
| CHEMBL52295 | — | — | 1 | 4.85 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.79 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301536 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL51660 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL52295 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 75000.0 | nM | 4.12 |