Assay Detail
Binding
CHEMBL683589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Folyl polyglutamate synthetase (FPGS)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Folylpolyglutamate synthase, mitochondrial (CHEMBL2890) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.44 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23977 | DIDEAZAFOLATE | — | 1 | 7.17 |
| CHEMBL89641 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23977 | DIDEAZAFOLATE | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL89641 | — | Ki | = | 2000.0 | nM | 5.70 |