Assay Detail
Functional
CHEMBL683606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nitrendipine binding to L-type calcium channel of Guinea pig cerebral cortex membranes
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A novel class of calcium-entry blockers: the 1[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.95 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174654 | — | — | 1 | 9.72 |
| CHEMBL425140 | — | — | 1 | 9.28 |
| CHEMBL285855 | FANTOFARONE | 2.0 | 1 | 9.21 |
| CHEMBL174677 | — | — | 1 | 9.21 |
| CHEMBL176242 | — | — | 1 | 9.21 |
| CHEMBL367248 | — | — | 1 | 9.13 |
| CHEMBL275684 | — | — | 1 | 9.08 |
| CHEMBL175023 | — | — | 1 | 9.05 |
| CHEMBL366696 | — | — | 1 | 8.92 |
| CHEMBL361586 | — | — | 1 | 8.89 |
| CHEMBL174394 | — | — | 1 | 8.74 |
| CHEMBL425680 | — | — | 1 | 8.72 |
| CHEMBL174880 | — | — | 1 | 8.68 |
| CHEMBL177224 | — | — | 1 | 8.64 |
| CHEMBL175642 | — | — | 1 | 8.64 |
| CHEMBL177447 | — | — | 1 | 8.60 |
| CHEMBL367563 | — | — | 1 | 8.59 |
| CHEMBL174788 | — | — | 1 | 8.40 |
| CHEMBL413354 | — | — | 1 | 8.35 |
| CHEMBL368850 | — | — | 1 | 8.35 |
| CHEMBL369468 | — | — | 1 | 8.34 |
| CHEMBL367670 | — | — | 1 | 8.34 |
| CHEMBL176456 | — | — | 1 | 8.20 |
| CHEMBL176496 | — | — | 1 | 8.18 |
| CHEMBL174768 | — | — | 1 | 8.06 |
| CHEMBL427480 | — | — | 1 | 8.02 |
| CHEMBL176759 | — | — | 1 | 7.85 |
| CHEMBL367297 | — | — | 1 | 7.85 |
| CHEMBL362484 | — | — | 1 | 7.85 |
| CHEMBL368728 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174654 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL425140 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL174677 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL176242 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL285855 | FANTOFARONE | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL367248 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL275684 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL175023 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL366696 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL361586 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL174394 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL425680 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL174880 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL177224 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL175642 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL177447 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL367563 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL174788 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL413354 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL368850 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL369468 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL367670 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL176456 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL176496 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL174768 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL427480 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL176759 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL367297 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL362484 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL368728 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL175000 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL368770 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL175118 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL177379 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL176407 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL177432 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL177578 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL175458 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL175078 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL177489 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL177869 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL425861 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL539422 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL175139 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL425317 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL355575 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL174681 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL367050 | — | IC50 | = | 5280.0 | nM | 5.28 |