Assay Detail
Functional
CHEMBL683620
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Inhibition of HCT116 cell proliferation in the presence of human serum albumin and alpha-1-acidglycoprotein
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.67 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325023 | — | — | 1 | 6.58 |
| CHEMBL114464 | — | — | 1 | 6.30 |
| CHEMBL326961 | — | — | 1 | 6.06 |
| CHEMBL323813 | — | — | 1 | 5.59 |
| CHEMBL119106 | — | — | 1 | 5.50 |
| CHEMBL114053 | — | — | 1 | 5.15 |
| CHEMBL332712 | — | — | 1 | 5.08 |
| CHEMBL116619 | — | — | 1 | 5.07 |
| CHEMBL115706 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325023 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL114464 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL326961 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL323813 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL119106 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL114053 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL332712 | — | IC50 | = | 8325.0 | nM | 5.08 |
| CHEMBL116619 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL115706 | — | IC50 | > | 19700.0 | nM | - |