Assay Detail
Binding
CHEMBL683649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against Geranylgeranyl transferase type I
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Ras farnesyltransferase: a new therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319274 | — | — | 1 | 7.30 |
| CHEMBL323507 | — | — | 1 | 6.70 |
| CHEMBL102295 | — | — | 1 | 5.85 |
| CHEMBL103575 | — | — | 1 | 5.00 |
| CHEMBL417600 | — | — | 1 | 4.00 |
| CHEMBL1790758 | — | — | 1 | - |
| CHEMBL103944 | — | — | 1 | - |
| CHEMBL289404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319274 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL323507 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL102295 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL103575 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL417600 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1790758 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103944 | — | IC50 | - | — | - | |
| CHEMBL289404 | — | IC50 | = | 114000.0 | nM | - |