Assay Detail
Functional
CHEMBL683681
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect upon disintegration catalyzed by the deletion mutant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.96 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 6.62 |
| CHEMBL59548 | — | — | 1 | 6.22 |
| CHEMBL100082 | — | — | 1 | 6.16 |
| CHEMBL39092 | — | — | 1 | 6.05 |
| CHEMBL58057 | — | — | 1 | 5.60 |
| CHEMBL36586 | — | — | 1 | 5.60 |
| CHEMBL59446 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL59548 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL100082 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL39092 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL58057 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL36586 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL59446 | — | IC50 | = | 3600.0 | nM | 5.44 |