Assay Detail
Functional
CHEMBL683690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect upon disintegration catalyzed by the (50-212) deletion mutant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.58 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287903 | — | — | 1 | 6.10 |
| CHEMBL38420 | — | — | 1 | 5.85 |
| CHEMBL39481 | — | — | 1 | 5.77 |
| CHEMBL431508 | — | — | 1 | 5.66 |
| CHEMBL40148 | — | — | 1 | 5.47 |
| CHEMBL39143 | — | — | 1 | 5.29 |
| CHEMBL39883 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287903 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL38420 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL39481 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL431508 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL40148 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL39143 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL39883 | — | IC50 | = | 12000.0 | nM | 4.92 |