Assay Detail
Functional
CHEMBL683697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid receptor activity in guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Opioid receptor (mu and kappa) (CHEMBL2111465) ↗| Type | SELECTIVITY GROUP |
| Organism | Cavia porcellus |
Publication
Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.59 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440446 | — | — | 1 | 9.80 |
| CHEMBL266515 | — | — | 1 | 9.72 |
| CHEMBL263597 | — | — | 1 | 9.72 |
| CHEMBL415330 | — | — | 1 | 9.62 |
| CHEMBL266717 | — | — | 1 | 9.60 |
| CHEMBL440987 | — | — | 1 | 9.59 |
| CHEMBL415617 | — | — | 1 | 9.57 |
| CHEMBL263583 | — | — | 1 | 9.47 |
| CHEMBL438741 | — | — | 1 | 9.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440446 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL266515 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL263597 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL415330 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL266717 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL440987 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL415617 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL263583 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL438741 | — | IC50 | = | 0.64 | nM | 9.19 |