Assay Detail
Functional
CHEMBL683810
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Antiviral activities against HIV-1 replication in CEM cells and its ability to lower the viral charge supernatants was reported
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.92 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37869 | — | — | 1 | 5.92 |
| CHEMBL39092 | — | — | 1 | 5.89 |
| CHEMBL40170 | — | — | 1 | 5.52 |
| CHEMBL37845 | — | — | 1 | 5.17 |
| CHEMBL37431 | — | — | 1 | 5.05 |
| CHEMBL36640 | — | — | 1 | 4.92 |
| CHEMBL39883 | — | — | 1 | 4.30 |
| CHEMBL37139 | — | — | 1 | 4.27 |
| CHEMBL36586 | — | — | 1 | 4.10 |
| CHEMBL418613 | — | — | 1 | 4.02 |
| CHEMBL38420 | — | — | 1 | - |
| CHEMBL39823 | — | — | 1 | - |
| CHEMBL39958 | — | — | 1 | - |
| CHEMBL39143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37869 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL39092 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL40170 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL37845 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL37431 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL36640 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL39883 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL37139 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL36586 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL418613 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL38420 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL39823 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL39958 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL39143 | — | IC50 | > | 100000.0 | nM | - |