Assay Detail
Functional
CHEMBL683816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against NNI-resistant HIV-1 strain A17 with Y181C,K103N mutation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.05 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432526 | — | — | 1 | 5.57 |
| CHEMBL417737 | — | — | 1 | 5.24 |
| CHEMBL302866 | — | — | 1 | 5.09 |
| CHEMBL294743 | — | — | 1 | 5.00 |
| CHEMBL292339 | — | — | 1 | 4.99 |
| CHEMBL295585 | — | — | 1 | 4.39 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | - |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432526 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL417737 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL302866 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL294743 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL292339 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL295585 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL39999 | TROVIRDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL593 | DELAVIRDINE | IC50 | > | 100000.0 | nM | - |