Assay Detail
Functional
CHEMBL683829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV-1 activity against mutant HIV-1 strain (100Leu-Ile) in CEM cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.29 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359315 | — | — | 1 | 6.99 |
| CHEMBL48427 | — | — | 1 | 6.82 |
| CHEMBL296589 | — | — | 1 | 6.12 |
| CHEMBL356190 | — | — | 1 | 6.03 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359315 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL48427 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL296589 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL356190 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL625 | THIABENDAZOLE | EC50 | = | 3120.0 | nM | 5.51 |