Assay Detail

CHEMBL683835

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Functional

Antiviral activity against HIV-1 protease

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Protease inhibitors: current status and future prospects.

Leung D, Abbenante G, Fairlie DP.
J Med Chem (2000) 43 : 305 -341
PubMed 10669559 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.55	7.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL13134	PALINAVIR	2.0	1	7.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL13134	PALINAVIR	EC50	=	28.0	nM	7.55