Assay Detail
Functional
CHEMBL683870
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In vitro cytotoxicity against human leukemic HL-60 cell line.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.35 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109928 | — | — | 1 | 7.82 |
| CHEMBL430884 | — | — | 1 | 7.75 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.68 |
| CHEMBL444329 | — | — | 1 | 7.60 |
| CHEMBL555714 | — | — | 1 | 7.60 |
| CHEMBL321473 | — | — | 1 | 7.60 |
| CHEMBL422252 | — | — | 1 | 7.55 |
| CHEMBL109534 | — | — | 1 | 6.38 |
| CHEMBL109942 | — | — | 1 | 6.17 |
| CHEMBL320495 | — | — | 1 | 6.02 |
| CHEMBL322491 | — | — | 1 | 5.98 |
| CHEMBL320354 | — | — | 1 | 5.83 |
| CHEMBL108493 | — | — | 1 | 5.81 |
| CHEMBL111735 | — | — | 1 | 5.74 |
| CHEMBL111261 | — | — | 1 | 5.71 |
| CHEMBL109922 | — | — | 1 | 5.57 |
| CHEMBL109880 | — | — | 1 | 5.55 |
| CHEMBL111502 | — | — | 1 | 5.48 |
| CHEMBL109468 | — | — | 1 | 5.37 |
| CHEMBL326274 | — | — | 1 | 5.30 |
| CHEMBL109743 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109928 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL430884 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL43 | AMSACRINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL444329 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL555714 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL321473 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL422252 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL109534 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL109942 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL320495 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL322491 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL320354 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL108493 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL111735 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL111261 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL109922 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL109880 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL111502 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL109468 | — | IC50 | = | 4295.0 | nM | 5.37 |
| CHEMBL326274 | — | IC50 | = | 4995.0 | nM | 5.30 |
| CHEMBL109743 | — | IC50 | = | 12850.0 | nM | 4.89 |