Assay Detail
Binding
CHEMBL684096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of human erythrocyte
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glyceraldehyde-3-phosphate dehydrogenase (CHEMBL2284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.12 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124807 | — | — | 1 | 5.89 |
| CHEMBL1775010 | — | — | 1 | 5.00 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 4.46 |
| CHEMBL2347288 | 2-METHYLADENOSINE | — | 1 | - |
| CHEMBL3142962 | — | — | 1 | - |
| CHEMBL3142963 | — | — | 1 | - |
| CHEMBL3142964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124807 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1775010 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL477 | ADENOSINE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2347288 | 2-METHYLADENOSINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL3142962 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3142963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3142964 | — | IC50 | > | 10000.0 | nM | - |