Assay Detail
Binding
CHEMBL684125
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In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Human glucagon receptor antagonists based on alkylidene hydrazides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.33 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152765 | — | — | 1 | 7.70 |
| CHEMBL348785 | — | — | 1 | 7.64 |
| CHEMBL158753 | — | — | 1 | 7.51 |
| CHEMBL161483 | — | — | 1 | 7.32 |
| CHEMBL158330 | — | — | 1 | 7.30 |
| CHEMBL348702 | — | — | 1 | 7.28 |
| CHEMBL346226 | — | — | 1 | 7.24 |
| CHEMBL153038 | — | — | 1 | 7.08 |
| CHEMBL159071 | — | — | 1 | 6.96 |
| CHEMBL154269 | — | — | 1 | 6.89 |
| CHEMBL351724 | — | — | 1 | 6.85 |
| CHEMBL161431 | — | — | 1 | 6.82 |
| CHEMBL161505 | — | — | 1 | 6.80 |
| CHEMBL159093 | — | — | 1 | 6.75 |
| CHEMBL107070 | — | — | 1 | 6.70 |
| CHEMBL160715 | — | — | 1 | 6.48 |
| CHEMBL421833 | — | — | 1 | 6.41 |
| CHEMBL161401 | — | — | 1 | 6.16 |
| CHEMBL444343 | — | — | 1 | 6.16 |
| CHEMBL435445 | — | — | 1 | 6.13 |
| CHEMBL161827 | — | — | 1 | 6.06 |
| CHEMBL157064 | — | — | 1 | 6.06 |
| CHEMBL160291 | — | — | 1 | 6.03 |
| CHEMBL160419 | — | — | 1 | 5.92 |
| CHEMBL160138 | — | — | 1 | 5.89 |
| CHEMBL160652 | — | — | 1 | 5.82 |
| CHEMBL161494 | — | — | 1 | 5.72 |
| CHEMBL158556 | — | — | 1 | 5.57 |
| CHEMBL160135 | — | — | 1 | 5.28 |
| CHEMBL351333 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152765 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL348785 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL158753 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL161483 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL158330 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL348702 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL346226 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL153038 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL159071 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL154269 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL351724 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL161431 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL161505 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL159093 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL107070 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL160715 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL421833 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL161401 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL444343 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL435445 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL161827 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL157064 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL160291 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL160419 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL160138 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL160652 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL161494 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL158556 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL160135 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL351333 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL158497 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL347370 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL158886 | — | IC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL160521 | — | IC50 | > | 100000.0 | nM | - |