Compound Detail
CHEMBL152765
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Basic Information
| ChEMBL ID | CHEMBL152765 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TZRBHYBSDPWVRW-WKULSOCRSA-N |
2
Targets
3
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
473.5
MW (Da)
4.75
ALogP
7
HBA
2
HBD
113.2
PSA (Ų)
0.34
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon receptor CHEMBL4720 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Glucagon receptor CHEMBL1985 | IC50 | 7.7 | 7.7 | 20.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 1.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon receptor | IC50 | = | 1.0 | nM | 9.0 | In vitro inhibitory activity against rat glucagon receptor using [127I]-labeled ... | 11844695 |
| Glucagon receptor | IC50 | = | 20.0 | nM | 7.7 | In vitro inhibitory activity against human glucagon receptor using [127I]-labele... | 11844695 |
| Glucagon receptor | IC50 | = | 20.0 | nM | 7.7 | In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK ... | 12477359 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11844695 | 10.1016/s0960-894x(01)00819-8 | Glucagon receptor | 2 |
| 11844695 | 10.1016/s0960-894x(01)00819-8 | Rattus norvegicus | 1 |
| 11844695 | 10.1016/s0960-894x(01)00819-8 | ADMET | 1 |
| 12477359 | 10.1021/jm0208572 | Glucagon receptor | 1 |
Data from ChEMBL 36 via Core Engine