Assay Detail
Binding
CHEMBL684169
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In vitro inhibition of Geranylgeranyl transferase type I
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.83 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75804 | — | — | 1 | 8.89 |
| CHEMBL74363 | — | — | 1 | 8.32 |
| CHEMBL73862 | — | — | 1 | 7.85 |
| CHEMBL311507 | — | — | 1 | 7.66 |
| CHEMBL310413 | — | — | 1 | 6.96 |
| CHEMBL75237 | — | — | 1 | 6.70 |
| CHEMBL77419 | — | — | 1 | 6.40 |
| CHEMBL75677 | — | — | 1 | 6.00 |
| CHEMBL312598 | — | — | 1 | 5.85 |
| CHEMBL308724 | — | — | 1 | 5.39 |
| CHEMBL78855 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75804 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL74363 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL73862 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL311507 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL310413 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL75237 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL77419 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL75677 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL312598 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL308724 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL78855 | — | IC50 | = | 8100.0 | nM | 5.09 |