Assay Detail
Functional
CHEMBL684259
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In vitro cytotoxicity against GCT cell lines
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GCT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.49 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133987 | TRIMELAMOL | — | 1 | 4.61 |
| CHEMBL422976 | — | — | 1 | 4.59 |
| CHEMBL135064 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133987 | TRIMELAMOL | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL422976 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL135064 | — | IC50 | = | 53900.0 | nM | 4.27 |