Assay Detail
Functional
CHEMBL684271
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Tested for 45 [Ca2+] uptake in rat pituitary growth hormone3 (GH3) cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | GH3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.81 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082832 | — | — | 1 | 7.82 |
| CHEMBL93655 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082832 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93655 | — | EC50 | = | 16.0 | nM | 7.80 |