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Target Snapshot

CHEMBL614571 Target Snapshot

GH3 · CELL-LINE · Rattus norvegicus

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39Compounds
31Assays
0Approved Drugs
24.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GH3 as ChEMBL target CHEMBL614571. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
GH3
CELL-LINE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL614571
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether GH3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameGH3
Target TypeCELL-LINE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGH3
UniProt AccessionN/A

GH3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as GH3.

Review nameGH3
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC506.0
EC5018.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1082832 7.82 EC50 15.0 Preclinical
CHEMBL93655 7.8 EC50 16.0 Preclinical
CHEMBL93689 7.05 EC50 89.0 Preclinical
CHEMBL4459850 6.85 IC50 140.0 Preclinical
CHEMBL355185 6.68 EC50 207.0 Preclinical
CHEMBL327598 6.38 EC50 420.0 Preclinical
CHEMBL420064 6.3 EC50 500.0 Preclinical
CHEMBL330509 6.22 EC50 600.0 Preclinical
CHEMBL171818 6.21 EC50 614.0 Preclinical
CHEMBL327446 5.89 EC50 1300.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
2
5.5
4
6.0
3
6.5
1
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

31
Total Assays
22
Tested Compounds
2
Assay Types
Functional — 27 assays, 22 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 22 6.0
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine